Tissue factor pathway inhibitor: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='Human tissue factor pathway inhibitor 2 Kunitz domain I (green) complex with trypsin (cyan) and Ca+2 ion (PDB code [[1zr0]])' scene='70/707370/Cv/1'> | ||
== Function == | == Function == | ||
'''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa<ref>PMID:9112630</ref>. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix. Kunitz I and II domains inhibit VIIa coagulation factor while Kunitz II domain inhibits Xa. Kunitz III domains probably involved in the interactions with lipoproteins. | '''Tissue factor pathway inhibitor''' (TFPI) is a protease inhibitor which inhibits coagulation factor Xa and VIIa<ref>PMID:9112630</ref>. TFPI contains three Kunitz domains. The Kunitz domain is disulfide-rich and is arranged to form a twisted two-stranded antiparallel β sheet followed by an α helix. Kunitz I and II domains inhibit VIIa coagulation factor while Kunitz II domain inhibits Xa. Kunitz III domains probably involved in the interactions with lipoproteins. | ||
| Line 12: | Line 12: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
Tissue factor pathway inhibitor domains: kunitz I 29-118; kunitz II 121-178; kunitz III 210-270 | |||
[[1adz]] – hTFPI-1 kunitz domain II (mutant) – human - NMR<br /> | [[1adz]] – hTFPI-1 kunitz domain II (mutant) – human - NMR<br /> | ||
| Line 17: | Line 19: | ||
[[1tfx]] – hTFPI-1 kunitz domain II + trypsin <br /> | [[1tfx]] – hTFPI-1 kunitz domain II + trypsin <br /> | ||
[[1zr0]] – hTFPI-2 kunitz domain I + trypsin <br /> | [[1zr0]] – hTFPI-2 kunitz domain I + trypsin <br /> | ||
[[5nmv]] – hTFPI-1 kunitz domain I + antibody <br /> | |||
[[4dtg]] – hTFPI-1 kunitz domain II + antibody <br /> | [[4dtg]] – hTFPI-1 kunitz domain II + antibody <br /> | ||
[[4bqd]] – hTFPI-1 kunitz domain I + peptide <br /> | [[4bqd]] – hTFPI-1 kunitz domain I + peptide <br /> | ||
