Gp41

spinqualitylabelsall models Core structure of acetylated gp41 from the HIV envelope glycoprotein, 1aik. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gp41 is a subunit of the envelope protein of retrovirus. Gp41 is a transmembrane protein and contains several sites which are involved in the infection of the host cells. Gp160 is the cleavable precursor of Gp41 and Gp120. For more details see Hiv env proteins. Relevance Fusion inhibitory drugs which bind to Gp41 prevent the attachment of the HIV-1 virus to the cell.

3D Structures of Gp41

Updated on 06-June-2018

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• Gp41 from HIV-1
  • Hiv env proteins, 1df4, 1df5, 1qr8, 1qr9, 1dlb, 1jpx – Gp41 thermostable core domain residues 544-579, 623-656
    
  • 1env, 3cp1, 3cyo, 1f23, 1k33, 1k34, 1i5x, 1i5y, 2ot5, 5ka6, 5ka5 – Gp41 thermostable core domain (mutant)
    
  • 3k9a – Gp41 residues 1-108 (mutant)
    
  • 1szt – Gp41 thermostable domain residues 541-574
    
  • 6b3u – Gp41 transmembrane domain residues 670-709 - NMR
    
  • 5vwl – Gp41 tail residues 750-854 - NMR
    
  • 2z2t, 2zzo, 3aha, 3vie, 2r3c, 2r5b, 2r5d, 3l36, 3l37, 3vgy, 3vh7, 3vtp, 3vu5, 3vu6, 5h0n – Gp41 N-heptad repeat + Gp41 fusion inhibitor peptide
    
  • 2zfc – Gp41 N-terminal residues 1-49
    
  • 3u91 – Gp41 N-terminal residues 7-39
    
  • 4hlr – Gp41 N-terminal (mutant)
    
  • 4i2l – Gp41 N-peptide residues 549-589 (mutant)
    
  • 5v8l, 5v8m, 5uty, 5utf, 5um8, 5jsa, 5js9, 5i8h, 5d9q, 5cjx, 5c7k, 6ck9, 6chb, 6ch9, 6ch8, 6ch7, 5w6d, 4nrx – Gp41 + Gp120 + antibody
    
  • 6cdi – Gp41 + Gp120 + antibody – Cryo EM
    
  • 5u1f, 5thr – Gp41 + Gp120 + antibody + CD4
    
  • 5fyk, 5fyj, 4nco – Gp41 + Gp120 (mutant) + antibody
    
  • 5hm1 – Gp41 + llama antibody
    
  • 3o3x – arGp41 - artificial
    
  • 4dzu – arGp41 + 3-α
    
  • 4dzv – arGp41 + 4-α/β
    
• Gp41 from Simian Immunodeficiency Virus
  • 2siv – Gp41 core
    
  • 2ezo, 2ezp, 2ezq, 2ezr, 2ezs, 1qce – Gp41 core - NMR
    
  • 1qbz, 1jq0 – Gp41 core (mutant)
    

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Michal Harel, Alexander Berchansky