Gag polyprotein: Difference between revisions

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<StructureSection load='2wlv' size='350' side='right' caption='Gag polyprotein N-terminal capsid domain of HIV-2 (PDB entry [[2wlv]])' scene=''>
<StructureSection load='2wlv' size='350' side='right' caption='Gag polyprotein N-terminal capsid domain of HIV-2 (PDB entry [[2wlv]])' scene=''>


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==Implications==
==Implications==
HIV-1 viral particles need to form a capsid cone-like structure prior to infection of the host cell. The protealytic cleavage of the immature Gag<sup>283</sup> polyprotein results in a capsid domain. This post-translational modification is essential to the formation of the core structure. Many studies have shown that the β-hairpin formed after maturation is essential for the capsid core particle formation <ref name="gitti"/><ref name="von"/>. As a result of the β-hairpin formation, the helix 6 is displaced causing an allosteric mechanism for CpyA binding. Overall, the maturation of Gag<sup>283</sup> and formation of the mature CA protein is essential for core capsid particle creation and consequently final infection.
HIV-1 viral particles need to form a capsid cone-like structure prior to infection of the host cell. The protealytic cleavage of the immature Gag<sup>283</sup> polyprotein results in a capsid domain. This post-translational modification is essential to the formation of the core structure. Many studies have shown that the β-hairpin formed after maturation is essential for the capsid core particle formation <ref name="gitti"/><ref name="von"/>. As a result of the β-hairpin formation, the helix 6 is displaced causing an allosteric mechanism for CpyA binding. Overall, the maturation of Gag<sup>283</sup> and formation of the mature CA protein is essential for core capsid particle creation and consequently final infection.
==3D structures of Gag polyprotein==
[[Gag polyprotein 3D structures]]
</StructureSection>
</StructureSection>
==3D structures of Gag polyprotein==
==3D structures of Gag polyprotein==
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**[[2h3i]] – Gag residues 2-132 – HIV-1<BR />
**[[2h3i]] – Gag residues 2-132 – HIV-1<BR />
**[[2h3f]], [[2h3i]], [[1uph]] - Gag residues 2-132 – NMR<BR />
**[[2h3f]], [[2h3i]], [[1uph]] - Gag residues 2-132 – NMR<BR />
**[[5mdg]], [[5mdf]], [[5mde]], [[5mdd]], [[5mdc]], [[5mdb]], [[5mda]], [[5md9]], [[5md8]], [[5md7]], [[5md6]], [[5md5]], [[5md4]], [[5md3]], [[5md2]], [[5md1]], [[5md0]], [[5mcz]] - Gag residues 1-221 – Cryo EM<br />
**[[1l6n]] - Gag residues 1-283 – NMR<BR />
**[[1l6n]] - Gag residues 1-283 – NMR<BR />
**[[1gwp]] - Gag residues 132-283 – NMR<BR />
**[[1gwp]] - Gag residues 132-283 – NMR<BR />
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**[[1baj]] – Gag C terminal<BR />
**[[1baj]] – Gag C terminal<BR />
**[[2znf]] – Gag zinc fingerlike domain - NMR<BR />
**[[2znf]] – Gag zinc fingerlike domain - NMR<BR />
**[[5teo]] - Gag residues 278-377 <br />
**[[6n3j]] - Gag residues 278-377 (mutant) <br />
**[[2h3q]], [[2h3v]], [[2h3z]] - Gag residues 2-132 + phosphatidyl inositol bisphosphate - NMR<BR />
**[[2h3q]], [[2h3v]], [[2h3z]] - Gag residues 2-132 + phosphatidyl inositol bisphosphate - NMR<BR />
**[[1mt7]], [[1mt8]] – Gag MA-CA cleavage site + protease retropepsin (mutant) <BR />
**[[1mt7]], [[1mt8]] – Gag MA-CA cleavage site + protease retropepsin (mutant) <BR />
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**[[1fgl]] – Gag residues 81-105 + cyclophilin A<BR />
**[[1fgl]] – Gag residues 81-105 + cyclophilin A<BR />
**[[2xde]] - Gag residues 1-146 + inhibitor<BR />
**[[2xde]] - Gag residues 1-146 + inhibitor<BR />
**[[4e91]], [[4e92]] - Gag residues 133-278 + inhibitor<br />
**[[4j91]], [[4j92]], [[4j93]] - Gag residues 133-278 + inhibitor<br />
**[[6n3u]] - Gag residues 278-377 (mutant) + inhibitor<br />
**[[2x2d]] - Gag residues 133-278 + peptidyl-prolyl cis-trans isomerase A<BR />
**[[2x2d]] - Gag residues 133-278 + peptidyl-prolyl cis-trans isomerase A<BR />
**[[2lf4]] - Gag residues 133-363 (mutant)<br />
**[[2lf4]] - Gag residues 133-363 (mutant)<br />
**[[4u0d]] - Gag residues 133-363 + Nup153 peptide<br />
**[[5upw]], [[5mcy]], [[5mcx]] - Gag residues 139-351 – Cryo EM<br />
**[[6ern]] - Gag residues 139-351 + ATP<br />
**[[6erm]] - Gag residues 139-351 + TTP derivative<br />
**[[6h09]], [[6es8]] - Gag residues 133-315 + inositol hexakisphosphate<br />
**[[2xt1]] – Gag C terminal + camelid VHH<br />
**[[2xt1]] – Gag C terminal + camelid VHH<br />
**[[1sje]], [[1sjh]] – Gag peptide + HLA-DR1<BR />
**[[1sje]], [[1sjh]] – Gag peptide + HLA-DR1<BR />
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**[[1eoq]] - Gag C terminal – NMR<BR />
**[[1eoq]] - Gag C terminal – NMR<BR />
**[[1a6s]] – Gag M domain (mutant) - NMR<BR />
**[[1a6s]] – Gag M domain (mutant) - NMR<BR />
**[[5a9e]] - Gag residues 84-577 – Cryo EM<br />


*Gag polyprotein from Simian immunodeficiency virus
*Gag polyprotein from Simian immunodeficiency virus
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**[[1u7k]], [[3bp9]] - Gag residues 215-345<BR />
**[[1u7k]], [[3bp9]] - Gag residues 215-345<BR />
**[[1u6p]] – Gag fragment + DNA – Moloney murine leukemia virus
**[[1u6p]] – Gag residues 479-534 + DNA <br />
**[[6mig]] - Gag residues 683-937 + DNA<br />


*Gag polyprotein from equine infectious anemia virus
*Gag polyprotein from equine infectious anemia virus
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**[[4jnh]] - Gag N terminal <br />
**[[4jnh]] - Gag N terminal <br />
**[[4jmr]] - Gag N terminal + Env protein<br />
**[[5m1h]], [[5m1g]] - Gag residues 300-477 - NMR<br />
}}
}}
==Additional Resources==
==Additional Resources==
Retrieved from "https://proteopedia.org/Gag_polyprotein"