5yls: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5yls is ~~ON HOLD~~

==Crystal structure of T2R-TTL-Y50 complex==

~~Authors~~: ~~Yang~~, J.H., ~~Chen~~, L.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5yls]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YLS FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~T2R~~-~~TTL~~-~~Y50 complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y50:E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one'>Y50</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yls OCA], [http://pdbe.org/5yls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yls RCSB], [http://www.ebi.ac.uk/pdbsum/5yls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yls ProSAT]</span></td></tr>

[[Category: Yang, J.H]]

</table>

[[Category: ~~Chen, L.J~~]]

== Function ==

[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/A0A287AGU7_PIG A0A287AGU7_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00031082]

== References ==

__TOC__

</StructureSection>

[[Category: Chen, L J]]

[[Category: Yang, J H]]

[[Category: Colchicine binding domain]]

[[Category: Millepachine]]

[[Category: Structural protein]]

[[Category: Tublin]]

[[Category: Tubulin inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yls is ON HOLD
+==Crystal structure of T2R-TTL-Y50 complex==
+<StructureSection load='5yls' size='340' side='right' caption='[[5yls]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Yang, J.H., Chen, L.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yls]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YLS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YLS FirstGlance]. <br>
-Description: Crystal structure of T2R-TTL-Y50 complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Y50:E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one'>Y50</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yls OCA], [http://pdbe.org/5yls PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yls RCSB], [http://www.ebi.ac.uk/pdbsum/5yls PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yls ProSAT]</span></td></tr>
-[[Category: Yang, J.H]]
+</table>
-[[Category: Chen, L.J]]
+== Function ==
+[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref>  [[http://www.uniprot.org/uniprot/A0A287AGU7_PIG A0A287AGU7_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00031082]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chen, L J]]
+[[Category: Yang, J H]]
+[[Category: Colchicine binding domain]]
+[[Category: Millepachine]]
+[[Category: Structural protein]]
+[[Category: Tublin]]
+[[Category: Tubulin inhibitor]]