Tryptophan synthase: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='Tryptophan synthase α subunit (yellow, salmon) and β subunit (cyan, green) of the α2β2 tetramer complex with pyridoxal-phosphate, glycerol-3-phosphate and Na+ ion (purple) [[1wbj]]' scene='52/525189/Cv/5'> | ||
== Function == | == Function == | ||
'''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan<ref>PMID:11893063</ref>. TrpS '''α subunit''' catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The '''β subunit''' catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. | '''Tryptophan synthase''' (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan<ref>PMID:11893063</ref>. TrpS '''α subunit''' catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The '''β subunit''' catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. | ||
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**[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br /> | **[[1x1q]] - TtTrpS β subunit – ''Thermus thermophilus''<br /> | ||
**[[2dh6]] - EcTrpS β subunit | **[[2dh6]] - EcTrpS β subunit - ''Escherichia coli''<br /> | ||
**[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br /> | **[[2o2e]], [[2o2j]] - MtTrpS β subunit – ''Mycobacterium tuberculosis''<br /> | ||
**[[1v8z]] - PfTrpS | **[[1v8z]] - PfTrpS β1 subunit <br /> | ||
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br /> | **[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br /> | ||
**[[4qys]] - | **[[4qys]] - SsTrpS β2 subunit – ''Sulfolobus solfataricus''<br /> | ||
*Tryptophan synthase β complex | *Tryptophan synthase β complex | ||
**[[2dh5]] - EcTrpS β subunit + PLP<br /> | **[[2dh5]] - EcTrpS β subunit + PLP<br /> | ||
**[[5dvz]] - PfTrpS | **[[6eqn]] - SsTrpS β2 subunit + PLP<br /> | ||
**[[5dw0]] - PfTrpS | **[[5dvz]] - PfTrpS β1 subunit + PLP derivative <br /> | ||
**[[5dw3]] - PfTrpS | **[[6am7]], [[6amc]], [[6cuv]] - PfTrpS β1 subunit (mutant) + PLP derivative <br /> | ||
**[[5t6m]] - PfTrpS | **[[5dw0]] - PfTrpS β1 subunit + Ser derivative <br /> | ||
**[[5vm5]] - PfTrpS | **[[5dw3]] - PfTrpS β1 subunit + PLP derivative + Trp<br /> | ||
**[[5ixj]] - PfTrpS | **[[6am8]], [[6ami]] - PfTrpS β1 subunit (mutant) + PLP derivative + Trp<br /> | ||
**[[5t6m]] - PfTrpS β1 subunit + PLP derivative + Trp derivative<br /> | |||
**[[5vm5]] - PfTrpS β1 subunit + PLP derivative + Ser derivative<br /> | |||
**[[5ixj]] - PfTrpS β1 subunit + PLP derivative + Thr<br /> | |||
**[[6am9]], [[6amh]] - PfTrpS β1 subunit (mutant) + PLP-Ser derivative <br /> | |||
**[[6cut]] - PfTrpS β1 subunit (mutant) + Trp analog <br /> | |||
**[[6cuz]] - PfTrpS β1 subunit (mutant) + PLP derivative + ethylserine<br /> | |||
*'''Tryptophan synthase α+β subunits''' | *'''Tryptophan synthase α+β subunits''' | ||
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**[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br /> | **[[5cgq]] - StTrpS α + β + Trp + inhibitor + PLP<br /> | ||
**[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br /> | **[[3cep]] - StTrpS α + β + G3P + indoline + PLP<br /> | ||
**[[6du1]], [[6dua]], [[6dwe]], [[6e9p]] - MtTrpS α + β + malonate + inhibitor + PLP derivative<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
