6bd5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6bd5 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of human CYP3A4 bound to an inhibitor==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6bd5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BD5 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BD5 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=D7M:tert-butyl+(2-{[(2R)-2-(cyclopentylamino)-3-oxo-3-{[(pyridin-3-yl)methyl]amino}propyl]sulfanyl}ethyl)carbamate'>D7M</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bd5 OCA], [http://pdbe.org/6bd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bd5 RCSB], [http://www.ebi.ac.uk/pdbsum/6bd5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bd5 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Sevrioukova, I]]

[[Category: Inhibitor]]

[[Category: Monooxygenase]]

[[Category: Oxidoreductase]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bd5 is ON HOLD  until Paper Publication
+==Crystal structure of human CYP3A4 bound to an inhibitor==
+<StructureSection load='6bd5' size='340' side='right' caption='[[6bd5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bd5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BD5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BD5 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D7M:tert-butyl+(2-{[(2R)-2-(cyclopentylamino)-3-oxo-3-{[(pyridin-3-yl)methyl]amino}propyl]sulfanyl}ethyl)carbamate'>D7M</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6bcz|6bcz]], [[6bd6|6bd6]], [[6bd7|6bd7]], [[6bd8|6bd8]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bd5 OCA], [http://pdbe.org/6bd5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bd5 RCSB], [http://www.ebi.ac.uk/pdbsum/6bd5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bd5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Sevrioukova, I]]
+[[Category: Inhibitor]]
+[[Category: Monooxygenase]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]