5mp0: Difference between revisions

<StructureSection load='5mp0' size='340' side='right'caption='[[5mp0]], [[Resolution|resolution]] 1.63&Aring;' scene=''>

<table><tr><td colspan='2'>[[5mp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MP0 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mp0 OCA], [https://pdbe.org/5mp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mp0 RCSB], [https://www.ebi.ac.uk/pdbsum/5mp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mp0 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/DCP2_HUMAN DCP2_HUMAN] Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).<ref>PMID:12218187</ref> <ref>PMID:12417715</ref> <ref>PMID:12486012</ref> <ref>PMID:12923261</ref> <ref>PMID:14527413</ref> <ref>PMID:18172165</ref> <ref>PMID:21070968</ref> <ref>PMID:26098573</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Burgess-Brown N]]

[[Category: Bushell SR]]

[[Category: Edwards AM]]

[[Category: Faust B]]

[[Category: Huber K]]

[[Category: Knapp S]]

[[Category: Mathea S]]

[[Category: Pike ACW]]

[[Category: Salah E]]

[[Category: Tallant C]]

[[Category: Velupillai S]]

[[Category: Wang D]]

[[Category: Von Delft F]]