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==Structure of PD-L1/small-molecule inhibitor complex==
==Structure of PD-L1/small-molecule inhibitor complex==
<StructureSection load='5n2d' size='340' side='right' caption='[[5n2d]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='5n2d' size='340' side='right'caption='[[5n2d]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5n2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2D FirstGlance]. <br>
<table><tr><td colspan='2'>[[5n2d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N2D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8J8:~{N}-[2-[[2,6-dimethoxy-4-[(2-methyl-3-phenyl-phenyl)methoxy]phenyl]methylamino]ethyl]ethanamide'>8J8</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8J8:~{N}-[2-[[2,6-dimethoxy-4-[(2-methyl-3-phenyl-phenyl)methoxy]phenyl]methylamino]ethyl]ethanamide'>8J8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2d OCA], [http://pdbe.org/5n2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2d RCSB], [http://www.ebi.ac.uk/pdbsum/5n2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2d OCA], [https://pdbe.org/5n2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n2d RCSB], [https://www.ebi.ac.uk/pdbsum/5n2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Dubin, G]]
[[Category: Large Structures]]
[[Category: Grudnik, P]]
[[Category: Dubin G]]
[[Category: Guzik, K]]
[[Category: Grudnik P]]
[[Category: Holak, T A]]
[[Category: Guzik K]]
[[Category: Zak, K M]]
[[Category: Holak TA]]
[[Category: Cell cycle]]
[[Category: Zak KM]]
[[Category: Pd-1]]
[[Category: Pd-l1]]
[[Category: Small-molecule inhibitor]]
Retrieved from "https://proteopedia.org/5n2d"