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==The structure of Staphylococcal Enterotoxin-like X (SElX), a Unique Superantigen==
==The structure of Staphylococcal Enterotoxin-like X (SElX), a Unique Superantigen==
<StructureSection load='5u75' size='340' side='right' caption='[[5u75]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
<StructureSection load='5u75' size='340' side='right'caption='[[5u75]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5u75]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U75 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5u75]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U75 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">selX, selx8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PRD_900122:Sialyl-Lewis+X+antigen,+alpha+anomer'>PRD_900122</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u75 OCA], [http://pdbe.org/5u75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u75 RCSB], [http://www.ebi.ac.uk/pdbsum/5u75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u75 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u75 OCA], [https://pdbe.org/5u75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u75 RCSB], [https://www.ebi.ac.uk/pdbsum/5u75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u75 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SELX_STAAU SELX_STAAU] Plays a role in the inhibition of the host innate immune system. Inhibits phagocytosis and killing by human neutrophils by interacting with multiple neutrophil surface glycoproteins in a sialic acid-dependent manner.<ref>PMID:28880913</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker, H]]
[[Category: Large Structures]]
[[Category: Fraser, J D]]
[[Category: Staphylococcus aureus]]
[[Category: Langley, R J]]
[[Category: Baker H]]
[[Category: Ting, Y T]]
[[Category: Fraser JD]]
[[Category: Young, P G]]
[[Category: Langley RJ]]
[[Category: Immune evasion molecule]]
[[Category: Ting YT]]
[[Category: Sialyl lewis x]]
[[Category: Young PG]]
[[Category: Staphylococcal superantigen]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/5u75"