5k26: Difference between revisions
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==Structure of the SH3 domain of MLK3 bound to peptide generated from phage display== | |||
<StructureSection load='5k26' size='340' side='right' caption='[[5k26]], [[Resolution|resolution]] 1.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5k26]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K26 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k28|5k28]]</td></tr> | ||
[[Category: Kall, S | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k26 OCA], [http://pdbe.org/5k26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k26 RCSB], [http://www.ebi.ac.uk/pdbsum/5k26 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k26 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/M3K11_HUMAN M3K11_HUMAN]] Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.<ref>PMID:12529434</ref> <ref>PMID:15258589</ref> <ref>PMID:8195146</ref> <ref>PMID:9003778</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kall, S K]] | |||
[[Category: Lavie, A]] | [[Category: Lavie, A]] | ||
[[Category: Mlk3]] | |||
[[Category: Phage display]] | |||
[[Category: Sh3]] | |||
[[Category: Signalling protein]] | |||
[[Category: Transferase]] | |||
Revision as of 06:53, 13 December 2017
Structure of the SH3 domain of MLK3 bound to peptide generated from phage display
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