5k28: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5k28 is ~~ON HOLD until Dec 13 2018~~

==Structure of the unbound SH3 domain of MLK3==

~~Authors~~: ~~Kall~~, S.K., ~~Lavie~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5k28]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K28 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K28 FirstGlance].

~~Description~~: ~~Structure~~ of the ~~unbound SH3 domain of MLK3~~

</td></tr><tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5k26|5k26]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </td></tr>

[[Category: Kall, S.K]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k28 OCA], [http://pdbe.org/5k28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k28 RCSB], [http://www.ebi.ac.uk/pdbsum/5k28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k28 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/M3K11_HUMAN M3K11_HUMAN]] Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.<ref>PMID:12529434</ref> <ref>PMID:15258589</ref> <ref>PMID:8195146</ref> <ref>PMID:9003778</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Mitogen-activated protein kinase kinase kinase]]

[[Category: Kall, S K]]

[[Category: Lavie, A]]

[[Category: Mlk3]]

[[Category: Phage display]]

[[Category: Sh3]]

[[Category: Signalling protein]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5k28 is ON HOLD  until Dec 13 2018
+==Structure of the unbound SH3 domain of MLK3==
+<StructureSection load='5k28' size='340' side='right' caption='[[5k28]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Kall, S.K., Lavie, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5k28]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K28 FirstGlance]. <br>
-Description: Structure of the unbound SH3 domain of MLK3
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k26|5k26]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr>
-[[Category: Kall, S.K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k28 OCA], [http://pdbe.org/5k28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k28 RCSB], [http://www.ebi.ac.uk/pdbsum/5k28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k28 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/M3K11_HUMAN M3K11_HUMAN]] Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.<ref>PMID:12529434</ref> <ref>PMID:15258589</ref> <ref>PMID:8195146</ref> <ref>PMID:9003778</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Mitogen-activated protein kinase kinase kinase]]
+[[Category: Kall, S K]]
 [[Category: Lavie, A]]
+[[Category: Mlk3]]
+[[Category: Phage display]]
+[[Category: Sh3]]
+[[Category: Signalling protein]]
+[[Category: Transferase]]