2a9l: Difference between revisions

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[[Image:2a9l.gif|left|200px]]
[[Image:2a9l.gif|left|200px]]


{{Structure
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{{STRUCTURE_2a9l| PDB=2a9l  | SCENE= }}  
|RELATEDENTRY=[[1a9l|1A9L]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9l OCA], [http://www.ebi.ac.uk/pdbsum/2a9l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a9l RCSB]</span>
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'''SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE'''
'''SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE'''
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==About this Structure==
==About this Structure==
2A9L is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9L OCA].  
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9L OCA].  


==Reference==
==Reference==
Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9660971 9660971]
Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9660971 9660971]
[[Category: Protein complex]]
[[Category: Diener, J L.]]
[[Category: Diener, J L.]]
[[Category: Moore, P B.]]
[[Category: Moore, P B.]]
[[Category: archaea]]
[[Category: Archaea]]
[[Category: archaeal bulge-helix-bulge motif]]
[[Category: Archaeal bulge-helix-bulge motif]]
[[Category: nmr]]
[[Category: Nmr]]
[[Category: pre-trna splicing]]
[[Category: Pre-trna splicing]]
[[Category: ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: rna structure]]
[[Category: Rna structure]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:47:01 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:49:45 2008''

Revision as of 15:47, 3 May 2008

File:2a9l.gif

Template:STRUCTURE 2a9l

SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE


Overview

The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNATrp has been determined by NMR spectroscopy. The conformations of the two 3 nt bulges, where the pre-tRNA is cleaved, are stabilized by stacking interactions between bulge nucleotides and bases in the adjacent Watson-Crick helices and by a network of backbone hydrogen bonds. Both bulges are presented on the same minor groove face of the central 4 bp helix, and the overall structure has approximate two-fold symmetry, which makes it well-suited for attack by archaeal splicing endonucleases, which are symmetric dimers.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971 Page seeded by OCA on Sat May 3 18:47:01 2008

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