5mr4: Difference between revisions
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==Ligand-receptor complex.== | |||
<StructureSection load='5mr4' size='340' side='right' caption='[[5mr4]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5mr4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MR4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mr5|5mr5]], [[5nmz|5nmz]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mr4 OCA], [http://pdbe.org/5mr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mr4 RCSB], [http://www.ebi.ac.uk/pdbsum/5mr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mr4 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Hirschsprung disease. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.<ref>PMID:9700200</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. [[http://www.uniprot.org/uniprot/GFRA2_HUMAN GFRA2_HUMAN]] Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.[UniProtKB:O08842] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Aagaard, A]] | |||
[[Category: Dahl, G]] | |||
[[Category: Oster, L]] | |||
[[Category: Roth, R G]] | |||
[[Category: Sandmark, J]] | |||
[[Category: Complex]] | |||
[[Category: Receptor]] | |||
[[Category: Signaling protein]] | |||
[[Category: Signalling]] | |||
