6ew8: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 6ew8 is ~~ON HOLD~~

==Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand==

~~Authors~~: ~~Robb~~, G., ~~Ferguson~~, A., ~~Hargreaves~~, D.

== Structural highlights ==

<table><tr><td colspan='2'>[[6ew8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EW8 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EW8 FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~the~~ BCL6 ~~BTB domain~~ in ~~complex with anilinopyrimidine ligand~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=C0Q:anilinopyrimidine+ligand'>C0Q</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ew8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ew8 OCA], [http://pdbe.org/6ew8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ew8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ew8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ew8 ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.

== Function ==

[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Ferguson, A]]

[[Category: Hargreaves, D]]

[[Category: Robb, G]]

[[Category: ~~Hargreaves, D~~]]

[[Category: Kinase]]

[[Category: ~~Ferguson, A~~]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ew8 is ON HOLD
+==Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand==
+<StructureSection load='6ew8' size='340' side='right' caption='[[6ew8]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
-Authors: Robb, G., Ferguson, A., Hargreaves, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ew8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EW8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EW8 FirstGlance]. <br>
-Description: Crystal structure of the BCL6 BTB domain in complex with anilinopyrimidine ligand
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C0Q:anilinopyrimidine+ligand'>C0Q</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5n21|5n21]], [[5n20|5n20]], [[5n1z|5n1z]], [[5n1x|5n1x]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ew8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ew8 OCA], [http://pdbe.org/6ew8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ew8 RCSB], [http://www.ebi.ac.uk/pdbsum/6ew8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ew8 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.
+== Function ==
+[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ferguson, A]]
+[[Category: Hargreaves, D]]
 [[Category: Robb, G]]
-[[Category: Hargreaves, D]]
+[[Category: Kinase]]
-[[Category: Ferguson, A]]
+[[Category: Transferase]]