Sandbox k11v: Difference between revisions
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The structure of K11V-TR was determined, even though glycine linkers and Val-to-Leu replacement,cylindrical bodies of three double stranded K11V-TR oligomers and six-stranded K11V were identical. | The structure of K11V-TR was determined, even though glycine linkers and Val-to-Leu replacement,cylindrical bodies of three double stranded K11V-TR oligomers and six-stranded K11V were identical. | ||
[[Image:K11vtrsideview.png | thumb | 400px | centre | Fig. 5 K11V-TR sideview ]] | |||
[[Image:Trtopview.png | thumb | 400px | centre | Fig. 6 K11V-TR Top view ]] | |||
There are proofs that amyloid oligomers are beta-sheet rich,and many toxic oligomers are recognized by A11 conformational antibody,which also recognizes cylindrin.Threfore, the cylindrin structure may represent amyloid oligomer's common structural core. | There are proofs that amyloid oligomers are beta-sheet rich,and many toxic oligomers are recognized by A11 conformational antibody,which also recognizes cylindrin.Threfore, the cylindrin structure may represent amyloid oligomer's common structural core. | ||
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[[Image:Names_all.jpg | thumb | 400px | left | Fig. 2 : Cylindrin single chain and tandem repeat peptide abbreviations and amino acid sequences. ]] | [[Image:Names_all.jpg | thumb | 400px | left | Fig. 2 : Cylindrin single chain and tandem repeat peptide abbreviations and amino acid sequences. ]] | ||
