4i18: Difference between revisions

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==Crystal structure of human prolactin receptor complexed with Fab fragment==
==Crystal structure of human prolactin receptor complexed with Fab fragment==
<StructureSection load='4i18' size='340' side='right' caption='[[4i18]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
<StructureSection load='4i18' size='340' side='right'caption='[[4i18]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4i18]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I18 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4i18]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I18 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i18 OCA], [https://pdbe.org/4i18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i18 RCSB], [https://www.ebi.ac.uk/pdbsum/4i18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i18 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i18 OCA], [http://pdbe.org/4i18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i18 RCSB], [http://www.ebi.ac.uk/pdbsum/4i18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i18 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN]] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>
[https://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[3D structures of antibody|3D structures of antibody]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Prolactin receptor|Prolactin receptor]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Duguid, E M]]
[[Category: Mus musculus]]
[[Category: Kouadio, J L]]
[[Category: Duguid EM]]
[[Category: Mukherjee, S]]
[[Category: Kouadio JL]]
[[Category: Cytokine]]
[[Category: Mukherjee S]]
[[Category: Immunoglobulin fold]]
[[Category: Prolactin binding]]
[[Category: Receptor signaling]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4i18"