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==Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity (glycosylated form)==
==Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity (glycosylated form)==
<StructureSection load='4lxs' size='340' side='right' caption='[[4lxs]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='4lxs' size='340' side='right'caption='[[4lxs]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LXS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LXS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e07|3e07]], [[4lxr|4lxr]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lxs OCA], [https://pdbe.org/4lxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lxs RCSB], [https://www.ebi.ac.uk/pdbsum/4lxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lxs ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tl, CG5490 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), spz, CG6134 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lxs OCA], [http://pdbe.org/4lxs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lxs RCSB], [http://www.ebi.ac.uk/pdbsum/4lxs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lxs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPZ_DROME SPZ_DROME]] Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo. Three proteases; ndl, gd and snk process easter to create active easter. Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo. Spz C-106 in the hemolymph controls expression of the antifungal peptide Drosomycin (Drs) by acting as a ligand of Tl and inducing an intracellular signaling pathway.<ref>PMID:8124709</ref> <ref>PMID:11212919</ref> <ref>PMID:8808632</ref> <ref>PMID:12872120</ref> 
[https://www.uniprot.org/uniprot/TOLL_DROME TOLL_DROME]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Breithaupt, C]]
[[Category: Large Structures]]
[[Category: Parthier, C]]
[[Category: Breithaupt C]]
[[Category: Stelter, M]]
[[Category: Parthier C]]
[[Category: Stubbs, M T]]
[[Category: Stelter M]]
[[Category: Cytokine receptor]]
[[Category: Stubbs MT]]
[[Category: Embryonic development]]
[[Category: Immune system]]
[[Category: Immune system-cytokine complex]]
[[Category: Innate immunity]]
[[Category: Leucine-rich repeat]]
[[Category: Receptor-ligand complex]]
[[Category: Tlr]]

Revision as of 10:39, 21 December 2022

Structure of the Toll - Spatzle complex, a molecular hub in Drosophila development and innate immunity (glycosylated form)

4lxs, resolution 3.30Å

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