2alv: Difference between revisions
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'''X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors''' | '''X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors''' | ||
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[[Category: 3cl]] | [[Category: 3cl]] | ||
[[Category: 3clpro]] | [[Category: 3clpro]] | ||
[[Category: | [[Category: Anti-viral]] | ||
[[Category: | [[Category: Coronavirus]] | ||
[[Category: | [[Category: Inhibitor]] | ||
[[Category: | [[Category: Protease]] | ||
[[Category: | [[Category: Proteinase]] | ||
[[Category: | [[Category: Sar]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:12:05 2008'' | |||
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Revision as of 16:12, 3 May 2008
X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors
Overview
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
About this Structure
2ALV is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632 Page seeded by OCA on Sat May 3 19:12:05 2008
