2aoz: Difference between revisions
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'''Crystal structure of the myotoxin-II from Atropoides nummifer venom''' | '''Crystal structure of the myotoxin-II from Atropoides nummifer venom''' | ||
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[[Category: Melo, C C.]] | [[Category: Melo, C C.]] | ||
[[Category: Murakami, M T.]] | [[Category: Murakami, M T.]] | ||
[[Category: | [[Category: Atropoides nummifer]] | ||
[[Category: | [[Category: Myotoxicity]] | ||
[[Category: | [[Category: Phospholipase a2]] | ||
[[Category: | [[Category: X-ray diffration]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:18:14 2008'' | |||
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Revision as of 16:18, 3 May 2008
Crystal structure of the myotoxin-II from Atropoides nummifer venom
Overview
Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.
About this Structure
2AOZ is a Single protein structure of sequence from Atropoides nummifer. Full crystallographic information is available from OCA.
Reference
Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766 Page seeded by OCA on Sat May 3 19:18:14 2008
