Virion infectivity factor: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='HIV-1 virion infectivity factor (deep sky blue) complex with human elongin-B (green) and elongin-C (pink) (PDB code [[2ma9]])' scene='75/750233/Cv/1'> | ||
== Function == | == Function == | ||
Virion infectivity factor (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. <scene name='75/750233/Cv/3'>Interactions between HIV-1 virion infectivity factor and human elongin-B and elongin-C</scene>. | '''Virion infectivity factor''' (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. <scene name='75/750233/Cv/3'>Interactions between HIV-1 virion infectivity factor and human elongin-B and elongin-C</scene>. | ||
For details see [[HIV and accessory proteins]] | For details see [[HIV and accessory proteins]] | ||
Revision as of 21:58, 5 October 2018
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3D Structures of virion infectivity factor
Updated on 05-October-2018
HIV and accessory proteins – Vif + cullin-5 + elongin-C + elongin-B + CBF-β – HIV-1
2ma9, 3dcg – Vif + elongin-C + elongin-B – HIV-1
