2b1p: Difference between revisions
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'''inhibitor complex of JNK3''' | '''inhibitor complex of JNK3''' | ||
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[[Category: Womack, P.]] | [[Category: Womack, P.]] | ||
[[Category: Xue, Y.]] | [[Category: Xue, Y.]] | ||
[[Category: | [[Category: Enzyme-inhibitor complex]] | ||
[[Category: | [[Category: Kinase inhibitor]] | ||
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Revision as of 16:44, 3 May 2008
inhibitor complex of JNK3
Overview
The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38alpha is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.
About this Structure
2B1P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3., Swahn BM, Huerta F, Kallin E, Malmstrom J, Weigelt T, Viklund J, Womack P, Xue Y, Ohberg L, Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9. PMID:16140012 Page seeded by OCA on Sat May 3 19:44:38 2008
