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==Crystal structure of Lgd-Shrub complex, single chain fusion==
==Crystal structure of Lgd-Shrub complex, single chain fusion==
<StructureSection load='5vo5' size='340' side='right' caption='[[5vo5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5vo5' size='340' side='right'caption='[[5vo5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vo5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VO5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VO5 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">shrb, Vps32, CG8055, Dmel_CG8055 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.004&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vo5 OCA], [http://pdbe.org/5vo5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vo5 RCSB], [http://www.ebi.ac.uk/pdbsum/5vo5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vo5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vo5 OCA], [https://pdbe.org/5vo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vo5 RCSB], [https://www.ebi.ac.uk/pdbsum/5vo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vo5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/C2D1_DROME C2D1_DROME]] Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling.<ref>PMID:12648493</ref> <ref>PMID:17088062</ref>
[https://www.uniprot.org/uniprot/C2D1_DROME C2D1_DROME] Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk. Also causes negative regulation of Notch during vein, eye, and bristle development. Acts by targeting Notch for endosomal degradation or recycling.<ref>PMID:12648493</ref> <ref>PMID:17088062</ref> [https://www.uniprot.org/uniprot/Q8T0Q4_DROME Q8T0Q4_DROME]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Blacklow, S C]]
[[Category: Large Structures]]
[[Category: McMillan, B J]]
[[Category: Blacklow SC]]
[[Category: Seegar, T C.M]]
[[Category: McMillan BJ]]
[[Category: Escrt]]
[[Category: Seegar TCM]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/5vo5"