5dfd: Difference between revisions
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==Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound== | ==Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound== | ||
<StructureSection load='5dfd' size='340' side='right' caption='[[5dfd]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='5dfd' size='340' side='right'caption='[[5dfd]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5dfd]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5dfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DFD FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=59E:METHYL+[(4S)-6-(1H-INDOL-4-YL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]ACETATE'>59E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=59E:METHYL+[(4S)-6-(1H-INDOL-4-YL)-8-METHOXY-1-METHYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]ACETATE'>59E</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dfd OCA], [https://pdbe.org/5dfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dfd RCSB], [https://www.ebi.ac.uk/pdbsum/5dfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dfd ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5dfd" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5dfd" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Baud | [[Category: Large Structures]] | ||
[[Category: Chirgadze | [[Category: Baud M]] | ||
[[Category: Ciulli | [[Category: Chirgadze DY]] | ||
[[Category: Lin-Shiao | [[Category: Ciulli A]] | ||
[[Category: Tallant | [[Category: Lin-Shiao E]] | ||
[[Category: Tallant C]] | |||
Revision as of 10:33, 21 June 2023
Crystal structure of BRD2(BD2) W370F mutant with ligand 28 bound
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