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==FLRT3 LRR domain in complex with LPHN3 Olfactomedin domain==
==FLRT3 LRR domain in complex with LPHN3 Olfactomedin domain==
<StructureSection load='5cmn' size='340' side='right' caption='[[5cmn]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='5cmn' size='340' side='right'caption='[[5cmn]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cmn]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CMN FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cmn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CMN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cmp|5cmp]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmn OCA], [https://pdbe.org/5cmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cmn RCSB], [https://www.ebi.ac.uk/pdbsum/5cmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmn ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FLRT3, KIAA1469, UNQ856/PRO1865 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), LPHN3, KIAA0768, LEC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmn OCA], [http://pdbe.org/5cmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cmn RCSB], [http://www.ebi.ac.uk/pdbsum/5cmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmn ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>
[https://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] May have a function in cell adhesion and/or receptor signaling. [[http://www.uniprot.org/uniprot/LPHN3_HUMAN LPHN3_HUMAN]] May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex (By similarity).  
[https://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN] May have a function in cell adhesion and/or receptor signaling.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5cmn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5cmn" style="background-color:#fffaf0;"></div>
==See Also==
*[[Latrophilin|Latrophilin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arac, D]]
[[Category: Large Structures]]
[[Category: Lu, Y]]
[[Category: Arac D]]
[[Category: Salzman, G]]
[[Category: Lu Y]]
[[Category: Adgrl3]]
[[Category: Salzman G]]
[[Category: Cell adhesion-carbohydrate binding complex]]
[[Category: Lrr repeat]]
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