5yav: Difference between revisions
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==Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction== | |||
<StructureSection load='5yav' size='340' side='right' caption='[[5yav]], [[Resolution|resolution]] 1.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5yav]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8SF:1-phenyl-5-propan-2-ylsulfanyl-1,2,3,4-tetrazole'>8SF</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yav OCA], [http://pdbe.org/5yav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yav RCSB], [http://www.ebi.ac.uk/pdbsum/5yav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yav ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bing, X]] | [[Category: Bing, X]] | ||
[[Category: Danyan, C]] | [[Category: Danyan, C]] | ||
[[Category: Yanlian, L]] | [[Category: Yanlian, L]] | ||
[[Category: Oncoprotein]] | |||
[[Category: Pde6delta]] | |||
Revision as of 10:00, 5 September 2018
Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction
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