5yf2: Difference between revisions
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==Crystal structure of CARNMT1 bound to anserine and SAH== | |||
<StructureSection load='5yf2' size='340' side='right' caption='[[5yf2]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5yf2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YF2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8V3:(2~{S})-2-(3-azanylpropanoylamino)-3-(3-methylimidazol-4-yl)propanoic+acid'>8V3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnosine_N-methyltransferase Carnosine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.22 2.1.1.22] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yf2 OCA], [http://pdbe.org/5yf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5yf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yf2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CARME_HUMAN CARME_HUMAN]] N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).<ref>PMID:26001783</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Carnosine N-methyltransferase]] | |||
[[Category: Cao, R]] | |||
[[Category: Li, H]] | [[Category: Li, H]] | ||
[[Category: | [[Category: Methyltransferase]] | ||
[[Category: Sam]] | |||
[[Category: Transferase]] | |||
Revision as of 18:39, 1 August 2018
Crystal structure of CARNMT1 bound to anserine and SAH
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