5ynp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5ynp ~~is ON HOLD until Paper Publication~~

==Crystal structure of MERS-CoV nsp16/nsp10 complex bound to sinefungin and m7GpppA==

~~Authors~~: ~~Wei, S~~.M., ~~Yang~~, L., ~~Ke, Z~~.H., ~~Guo~~, D.Y., ~~Fan~~, C.P.

== Structural highlights ==

<table><tr><td colspan='2'>[[5ynp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YNP FirstGlance]. <br>

~~Description~~: ~~Crystal structure of MERS~~-~~CoV nsp16~~/~~nsp10 complex bound to sinefungin and m7GpppA~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ynp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ynp OCA], [http://pdbe.org/5ynp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ynp RCSB], [http://www.ebi.ac.uk/pdbsum/5ynp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ynp ProSAT]</span></td></tr>

[[Category: Ke, Z.H]]

</table>

[[Category: ~~Fan~~, ~~C.P~~]]

== Function ==

[[http://www.uniprot.org/uniprot/K4LC41_9BETC K4LC41_9BETC]] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).[SAAS:SAAS014829_004_014545] Nsp9 is a ssRNA-binding protein (By similarity).[SAAS:SAAS014829_004_001449]

__TOC__

</StructureSection>

[[Category: Fan, C P]]

[[Category: Guo, D Y]]

[[Category: Ke, Z H]]

[[Category: Wei, S M]]

[[Category: Yang, L]]

[[Category: ~~Guo, D.Y~~]]

[[Category: Complex]]

[[Category: ~~Wei, S.M~~]]

[[Category: Inhibitor]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5ynp is ON HOLD  until Paper Publication
+==Crystal structure of MERS-CoV nsp16/nsp10 complex bound to sinefungin and m7GpppA==
+<StructureSection load='5ynp' size='340' side='right' caption='[[5ynp]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
-Authors: Wei, S.M., Yang, L., Ke, Z.H., Guo, D.Y., Fan, C.P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ynp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YNP FirstGlance]. <br>
-Description: Crystal structure of MERS-CoV nsp16/nsp10 complex bound to sinefungin and m7GpppA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ynp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ynp OCA], [http://pdbe.org/5ynp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ynp RCSB], [http://www.ebi.ac.uk/pdbsum/5ynp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ynp ProSAT]</span></td></tr>
-[[Category: Ke, Z.H]]
+</table>
-[[Category: Fan, C.P]]
+== Function ==
+[[http://www.uniprot.org/uniprot/K4LC41_9BETC K4LC41_9BETC]] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).[SAAS:SAAS014829_004_014545]  Nsp9 is a ssRNA-binding protein (By similarity).[SAAS:SAAS014829_004_001449]
+__TOC__
+</StructureSection>
+[[Category: Fan, C P]]
+[[Category: Guo, D Y]]
+[[Category: Ke, Z H]]
+[[Category: Wei, S M]]
 [[Category: Yang, L]]
-[[Category: Guo, D.Y]]
+[[Category: Complex]]
-[[Category: Wei, S.M]]
+[[Category: Inhibitor]]
+[[Category: Transferase]]