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'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN''' | '''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN''' | ||
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[[Category: Nelson, W J.]] | [[Category: Nelson, W J.]] | ||
[[Category: Weis, W I.]] | [[Category: Weis, W I.]] | ||
[[Category: | [[Category: Armadillo repeat]] | ||
[[Category: | [[Category: Beta-catenin]] | ||
[[Category: | [[Category: Structural protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:07:22 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 17:07, 3 May 2008
THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN
Overview
Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.
About this Structure
2BCT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899 Page seeded by OCA on Sat May 3 20:07:22 2008
