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==Crystal structure of PLpro from Middle East Respiratory Syndrome (MERS) coronavirus==
==Crystal structure of PLpro from Middle East Respiratory Syndrome (MERS) coronavirus==
<StructureSection load='4rna' size='340' side='right' caption='[[4rna]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
<StructureSection load='4rna' size='340' side='right'caption='[[4rna]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rna]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_betacoronavirus_2c_emc/2012 Human betacoronavirus 2c emc/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RNA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rna]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betacoronavirus_2c_EMC/2012 Human betacoronavirus 2c EMC/2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RNA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rna OCA], [https://pdbe.org/4rna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rna RCSB], [https://www.ebi.ac.uk/pdbsum/4rna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rna ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pt5|4pt5]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">orf1ab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1235996 Human betacoronavirus 2c EMC/2012])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rna OCA], [http://pdbe.org/4rna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rna RCSB], [http://www.ebi.ac.uk/pdbsum/4rna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rna ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/K4LC41_9BETC K4LC41_9BETC]] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).[SAAS:SAAS014829_004_014545]  Nsp9 is a ssRNA-binding protein (By similarity).[SAAS:SAAS014829_004_001449]  
[https://www.uniprot.org/uniprot/K4LC41_MERS K4LC41_MERS]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4rna" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4rna" style="background-color:#fffaf0;"></div>
==See Also==
*[[Virus protease 3D structures|Virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human betacoronavirus 2c emc/2012]]
[[Category: Human betacoronavirus 2c EMC/2012]]
[[Category: Johnson, M E]]
[[Category: Large Structures]]
[[Category: Lee, H]]
[[Category: Johnson ME]]
[[Category: Lei, H]]
[[Category: Lee H]]
[[Category: Santarsiero, B D]]
[[Category: Lei H]]
[[Category: Coronavirus]]
[[Category: Santarsiero BD]]
[[Category: Hydrolase]]
[[Category: Mer]]
[[Category: Papain-like protease]]
[[Category: Plpro]]
Retrieved from "https://proteopedia.org/4rna"