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==2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae==
==2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae==
<StructureSection load='4rob' size='340' side='right' caption='[[4rob]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4rob' size='340' side='right'caption='[[4rob]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rob]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ROB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rob]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ROB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ROB FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ro9|4ro9]], [[4roa|4roa]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rob OCA], [https://pdbe.org/4rob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rob RCSB], [https://www.ebi.ac.uk/pdbsum/4rob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rob ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRPN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rob OCA], [http://pdbe.org/4rob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rob RCSB], [http://www.ebi.ac.uk/pdbsum/4rob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rob ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SP2_ANOGA SP2_ANOGA] Serine protease inhibitor that functions in the melanization-mediated immune response (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing the activation of phenoloxidases through the inhibiting of serine proteases CLIPB9 and CLIPB10, negatively regulates melanization in the hemolymph (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing melanization, has a detrimental role during P.berghei parasite mediated-infection and invasion of the mosquito midgut (PubMed:16113656).<ref>PMID:16113656</ref> <ref>PMID:20953892</ref> <ref>PMID:21465556</ref> <ref>PMID:25525260</ref> <ref>PMID:33045027</ref> <ref>PMID:33520733</ref>
==See Also==
*[[Serpin 3D structures|Serpin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anoga]]
[[Category: Anopheles gambiae]]
[[Category: An, C]]
[[Category: Large Structures]]
[[Category: Battaile, K P]]
[[Category: An C]]
[[Category: Lovell, S]]
[[Category: Battaile KP]]
[[Category: Meekins, D A]]
[[Category: Lovell S]]
[[Category: Michel, K]]
[[Category: Meekins DA]]
[[Category: Zhang, X]]
[[Category: Michel K]]
[[Category: Hydrolase inhibitor]]
[[Category: Zhang X]]
[[Category: Insect immunity]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]
Retrieved from "https://proteopedia.org/4rob"