4run: Difference between revisions

Revision as of 08:28, 8 March 2023

Crystal structure of human odorant binding protein OBPIIa

Structural highlights

4run is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	FLC
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OBP2A_HUMAN Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.^[1]

Publication Abstract from PubMed

Human odorant-binding protein, OBPIIa , is expressed by nasal epithelia to facilitate transport of hydrophobic odorant molecules across the aqueous mucus. Here, we report its crystallographic analysis at 2.6 A resolution. OBPIIa is a monomeric protein that exhibits the classical lipocalin fold with a conserved eight-stranded beta-barrel harboring a remarkably large hydrophobic pocket. Basic residues within the four loops that shape the entrance to this ligand-binding site evoke a positive electrostatic potential. Human OBPIIa shows distinct features compared with other mammalian OBPs, including a potentially reactive Cys side chain within its pocket similar to human tear lipocalin. Proteins 2015. (c) 2015 Wiley Periodicals, Inc.

Crystal structure of the human odorant binding protein, OBP.,Schiefner A, Freier R, Eichinger A, Skerra A Proteins. 2015 Mar 21. doi: 10.1002/prot.24797. PMID:25810031^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Briand L, Eloit C, Nespoulous C, Bezirard V, Huet JC, Henry C, Blon F, Trotier D, Pernollet JC. Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. Biochemistry. 2002 Jun 11;41(23):7241-52. PMID:12044155
↑ Schiefner A, Freier R, Eichinger A, Skerra A. Crystal structure of the human odorant binding protein, OBP. Proteins. 2015 Mar 21. doi: 10.1002/prot.24797. PMID:25810031 doi:https://dx.doi.org/10.1002/prot.24797

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OCA

[1] Briand L, Eloit C, Nespoulous C, Bezirard V, Huet JC, Henry C, Blon F, Trotier D, Pernollet JC. Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. Biochemistry. 2002 Jun 11;41(23):7241-52. PMID:12044155

[2] Schiefner A, Freier R, Eichinger A, Skerra A. Crystal structure of the human odorant binding protein, OBP. Proteins. 2015 Mar 21. doi: 10.1002/prot.24797. PMID:25810031 doi:https://dx.doi.org/10.1002/prot.24797

[1]

[2]

@@ Line 1: / Line 1: @@
 ==Crystal structure of human odorant binding protein OBPIIa==
-<StructureSection load='4run' size='340' side='right' caption='[[4run]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='4run' size='340' side='right'caption='[[4run]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4run]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4run]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RUN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OBP2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4run FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4run OCA], [https://pdbe.org/4run PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4run RCSB], [https://www.ebi.ac.uk/pdbsum/4run PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4run ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4run FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4run OCA], [http://pdbe.org/4run PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4run RCSB], [http://www.ebi.ac.uk/pdbsum/4run PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4run ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/OBP2A_HUMAN OBP2A_HUMAN]] Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.<ref>PMID:12044155</ref>
+[https://www.uniprot.org/uniprot/OBP2A_HUMAN OBP2A_HUMAN] Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.<ref>PMID:12044155</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 18: @@
 </div>
 <div class="pdbe-citations 4run" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Schiefner, A]]
+[[Category: Large Structures]]
-[[Category: Skerra, A]]
+[[Category: Schiefner A]]
-[[Category: Aliphatic aldehyde]]
+[[Category: Skerra A]]
-[[Category: Fatty acid]]
-[[Category: Human lipocalin]]
-[[Category: Lilial]]
-[[Category: Lipid binding protein]]
-[[Category: Nasal mucus]]
-[[Category: Odorant-binding protein]]
-[[Category: Transport protein]]
-[[Category: Vanillin]]

4run: Difference between revisions

Revision as of 08:28, 8 March 2023

Crystal structure of human odorant binding protein OBPIIa

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

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