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==Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)==
==Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)==
<StructureSection load='4s0o' size='340' side='right' caption='[[4s0o]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4s0o' size='340' side='right'caption='[[4s0o]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4s0o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4s0o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0O FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s0p|4s0p]], [[1f16|1f16]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0o OCA], [https://pdbe.org/4s0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0o RCSB], [https://www.ebi.ac.uk/pdbsum/4s0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0o ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAX, BCL2L4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0o OCA], [http://pdbe.org/4s0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0o RCSB], [http://www.ebi.ac.uk/pdbsum/4s0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4s0o" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4s0o" style="background-color:#fffaf0;"></div>
==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Gavathiotis, E]]
[[Category: Large Structures]]
[[Category: Priyadarshi, A]]
[[Category: Gavathiotis E]]
[[Category: Apoptosis]]
[[Category: Priyadarshi A]]
[[Category: Apoptosis regulator]]
[[Category: Autoinhibited dimer]]
[[Category: Bcl-2 family protein]]
Retrieved from "https://proteopedia.org/4s0o"