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==Crystal Structure of Mtb PEPCK in complex with PEP==
==Crystal Structure of Mtb PEPCK in complex with PEP==
<StructureSection load='4wpt' size='340' side='right' caption='[[4wpt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4wpt' size='340' side='right'caption='[[4wpt]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wpt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WPT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wpt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WPT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wou|4wou]], [[4wl8|4wl8]], [[4wiu|4wiu]], [[4wpu|4wpu]], [[4wpv|4wpv]], [[4pie|4pie]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wpt OCA], [https://pdbe.org/4wpt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wpt RCSB], [https://www.ebi.ac.uk/pdbsum/4wpt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wpt ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pckG, MRA_0219 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=419947 MYCTA])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wpt OCA], [http://pdbe.org/4wpt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wpt RCSB], [http://www.ebi.ac.uk/pdbsum/4wpt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wpt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PCKG_MYCTA PCKG_MYCTA]] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.  
[https://www.uniprot.org/uniprot/PCKG_MYCTA PCKG_MYCTA] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
 
==See Also==
*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycta]]
[[Category: Large Structures]]
[[Category: Kim, H L]]
[[Category: Mycobacterium tuberculosis H37Ra]]
[[Category: Krieger, I V]]
[[Category: Kim HL]]
[[Category: Sacchettini, J C]]
[[Category: Krieger IV]]
[[Category: Anaplerotic reaction]]
[[Category: Sacchettini JC]]
[[Category: Gtp-dependent pepck]]
[[Category: Lyase]]
[[Category: Omega-loop]]
[[Category: P-loop]]
[[Category: R-loop]]
[[Category: Transferase]]

Revision as of 07:20, 7 April 2023

Crystal Structure of Mtb PEPCK in complex with PEP

4wpt, resolution 1.60Å

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