4x2l: Difference between revisions

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==Crystal structure of human BACE-1 bound to Compound 6==
==Crystal structure of human BACE-1 bound to Compound 6==
<StructureSection load='4x2l' size='340' side='right' caption='[[4x2l]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='4x2l' size='340' side='right'caption='[[4x2l]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4x2l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X2L FirstGlance]. <br>
<table><tr><td colspan='2'>[[4x2l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X2L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3WP:(4S)-4-(2,4-DIFLUOROPHENYL)-4-METHYL-5,6-DIHYDRO-4H-1,3-THIAZIN-2-AMINE'>3WP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3WP:(4S)-4-(2,4-DIFLUOROPHENYL)-4-METHYL-5,6-DIHYDRO-4H-1,3-THIAZIN-2-AMINE'>3WP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x2l OCA], [https://pdbe.org/4x2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x2l RCSB], [https://www.ebi.ac.uk/pdbsum/4x2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x2l ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x2l OCA], [http://pdbe.org/4x2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x2l RCSB], [http://www.ebi.ac.uk/pdbsum/4x2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x2l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4x2l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4x2l" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Large Structures]]
[[Category: Parris, K]]
[[Category: Parris K]]
[[Category: Vajdos, F F]]
[[Category: Vajdos FF]]
[[Category: Beta-secretase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Protease]]
Retrieved from "https://proteopedia.org/4x2l"