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==Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2==
==Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2==
<StructureSection load='4x8k' size='340' side='right' caption='[[4x8k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4x8k' size='340' side='right'caption='[[4x8k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4x8k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X8K FirstGlance]. <br>
<table><tr><td colspan='2'>[[4x8k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X8K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sigA, mysA, rpoD, rpoV, MT2777 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), rbpA, MT2110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x8k OCA], [https://pdbe.org/4x8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x8k RCSB], [https://www.ebi.ac.uk/pdbsum/4x8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x8k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x8k OCA], [http://pdbe.org/4x8k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x8k RCSB], [http://www.ebi.ac.uk/pdbsum/4x8k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x8k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIGA_MYCTO SIGA_MYCTO]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.[HAMAP-Rule:MF_00963] [[http://www.uniprot.org/uniprot/RBPA_MYCTO RBPA_MYCTO]] Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
[https://www.uniprot.org/uniprot/SIGA_MYCTU SIGA_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth (Probable).<ref>PMID:12354223</ref> <ref>PMID:20729364</ref> <ref>PMID:22570422</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4x8k" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4x8k" style="background-color:#fffaf0;"></div>
==See Also==
*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Campbell, E A]]
[[Category: Large Structures]]
[[Category: Darst, S A]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Flack, J E]]
[[Category: Campbell EA]]
[[Category: Hubin, E A]]
[[Category: Darst SA]]
[[Category: Paget, M S]]
[[Category: Flack JE]]
[[Category: Tabib-Salazar, A]]
[[Category: Hubin EA]]
[[Category: Sigma factor]]
[[Category: Paget MS]]
[[Category: Transcription activator]]
[[Category: Tabib-Salazar A]]
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