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==Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)==
==Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)==
<StructureSection load='5tvc' size='340' side='right' caption='[[5tvc]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='5tvc' size='340' side='right'caption='[[5tvc]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5tvc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TVC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5tvc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TVC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=7LB:(E,2S)-N-METHYL-5-(5-PHENOXY-3-PYRIDYL)PENT-4-EN-2-AMINE'>7LB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.926&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA3, NACHRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6500 APLCA])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=7LB:(E,2S)-N-METHYL-5-(5-PHENOXY-3-PYRIDYL)PENT-4-EN-2-AMINE'>7LB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvc OCA], [http://pdbe.org/5tvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tvc RCSB], [http://www.ebi.ac.uk/pdbsum/5tvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvc OCA], [https://pdbe.org/5tvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tvc RCSB], [https://www.ebi.ac.uk/pdbsum/5tvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACHA3_HUMAN ACHA3_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
==See Also==
*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aplca]]
[[Category: Aplysia californica]]
[[Category: Bobango, J]]
[[Category: Homo sapiens]]
[[Category: Talley, I T]]
[[Category: Large Structures]]
[[Category: Talley, T T]]
[[Category: Bobango J]]
[[Category: Wu, J]]
[[Category: Talley IT]]
[[Category: Acetylcholine]]
[[Category: Talley TT]]
[[Category: Acetylcholine-binding protein]]
[[Category: Wu J]]
[[Category: Achbp]]
[[Category: Chimeric protein]]
[[Category: Nicotinic]]
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