6bco: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6bco is ~~ON HOLD~~ ~~until Paper Publication~~

==cryo-EM structure of TRPM4 in ATP bound state with short coiled coil at 2.9 angstrom resolution==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6bco]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BCO OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BCO FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6bcj|6bcj]], [[6bcl|6bcl]], [[6bcq|6bcq]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bco OCA], [http://pdbe.org/6bco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bco RCSB], [http://www.ebi.ac.uk/pdbsum/6bco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bco ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TRPM4_MOUSE TRPM4_MOUSE]] Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells.<ref>PMID:17188667</ref> <ref>PMID:18758465</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Bai, X]]

[[Category: Chen, Q]]

[[Category: Guo, J]]

[[Category: Jiang, Y]]

[[Category: She, J]]

[[Category: Ion channel]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bco is ON HOLD  until Paper Publication
+==cryo-EM structure of TRPM4 in ATP bound state with short coiled coil at 2.9 angstrom resolution==
+<StructureSection load='6bco' size='340' side='right' caption='[[6bco]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bco]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BCO FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6bcj|6bcj]], [[6bcl|6bcl]], [[6bcq|6bcq]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bco OCA], [http://pdbe.org/6bco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bco RCSB], [http://www.ebi.ac.uk/pdbsum/6bco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bco ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TRPM4_MOUSE TRPM4_MOUSE]] Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells.<ref>PMID:17188667</ref> <ref>PMID:18758465</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bai, X]]
+[[Category: Chen, Q]]
+[[Category: Guo, J]]
+[[Category: Jiang, Y]]
+[[Category: She, J]]
+[[Category: Ion channel]]
+[[Category: Transport protein]]