6f4z: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6f4z is ~~ON HOLD~~

==2'F-araG modified quadruplex with flipped G-tract and central tetrad==

== Structural highlights ==

<table><tr><td colspan='2'>[[6f4z]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F4Z FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFL:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>GFL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f4z OCA], [http://pdbe.org/6f4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f4z RCSB], [http://www.ebi.ac.uk/pdbsum/6f4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f4z ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

A (3+1)-hybrid-type G-quadruplex was substituted within its central tetrad by a single 2'-fluoro-modified guanosine. Driven by the anti-favoring nucleoside analogue, a novel quadruplex fold with inversion of a single G-tract and conversion of a propeller loop into a lateral loop emerges. In addition, scalar couplings across hydrogen bonds demonstrate the formation of intra- and inter-residual FH8-C8 pseudo-hydrogen bonds within the modified quadruplexes. Alternative folding can be rationalized by the impact of fluorine on intermediate species on the basis of a kinetic partitioning mechanism. Apparently, chemical or other environmental perturbations are able to redirect folding of a quadruplex, possibly modulating its regulatory role in physiological processes.

~~Authors:~~ Dickerhoff, J., Weisz, K.

Fluorine-Mediated Editing of a G-Quadruplex Folding Pathway.,Dickerhoff J, Weisz K Chembiochem. 2018 Feb 20. doi: 10.1002/cbic.201800099. PMID:29460996<ref>PMID:29460996</ref>

~~Description: 2'F~~-~~araG modified quadruplex with flipped G~~-~~tract and central tetrad~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~[[Category: Unreleased Structures]]~~

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Dickerhoff, J]]

[[Category: Weisz, K]]

[[Category: 2'f-ana]]

[[Category: Dna]]

[[Category: G-quadruplex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6f4z is ON HOLD
+==2'F-araG modified quadruplex with flipped G-tract and central tetrad==
+<StructureSection load='6f4z' size='340' side='right' caption='[[6f4z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6f4z]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F4Z FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GFL:2-AMINO-9-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>GFL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f4z OCA], [http://pdbe.org/6f4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f4z RCSB], [http://www.ebi.ac.uk/pdbsum/6f4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f4z ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A (3+1)-hybrid-type G-quadruplex was substituted within its central tetrad by a single 2'-fluoro-modified guanosine. Driven by the anti-favoring nucleoside analogue, a novel quadruplex fold with inversion of a single G-tract and conversion of a propeller loop into a lateral loop emerges. In addition, scalar couplings across hydrogen bonds demonstrate the formation of intra- and inter-residual FH8-C8 pseudo-hydrogen bonds within the modified quadruplexes. Alternative folding can be rationalized by the impact of fluorine on intermediate species on the basis of a kinetic partitioning mechanism. Apparently, chemical or other environmental perturbations are able to redirect folding of a quadruplex, possibly modulating its regulatory role in physiological processes.
-Authors: Dickerhoff, J., Weisz, K.
+Fluorine-Mediated Editing of a G-Quadruplex Folding Pathway.,Dickerhoff J, Weisz K Chembiochem. 2018 Feb 20. doi: 10.1002/cbic.201800099. PMID:29460996<ref>PMID:29460996</ref>
-Description: 2'F-araG modified quadruplex with flipped G-tract and central tetrad
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6f4z" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Dickerhoff, J]]
 [[Category: Weisz, K]]
+[[Category: 2'f-ana]]
+[[Category: Dna]]
+[[Category: G-quadruplex]]