6f5b: Difference between revisions
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==Structure of ARTD2/PARP2 WGR domain bound to double stranded DNA with 5'phosphate== | |||
<StructureSection load='6f5b' size='340' side='right' caption='[[6f5b]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6f5b]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F5B FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f5b OCA], [http://pdbe.org/6f5b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f5b RCSB], [http://www.ebi.ac.uk/pdbsum/6f5b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f5b ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Haikarainen, T]] | |||
[[Category: Lehtio, L]] | |||
[[Category: Obaji, E]] | |||
[[Category: Adp-ribosylation]] | |||
[[Category: Artd2]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Dna end joining]] | |||
[[Category: Dna repair]] | |||
[[Category: Phosphorylated dna]] | |||
