5ocz: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ocz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ocz OCA], [http://pdbe.org/5ocz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ocz RCSB], [http://www.ebi.ac.uk/pdbsum/5ocz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ocz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ocz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ocz OCA], [http://pdbe.org/5ocz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ocz RCSB], [http://www.ebi.ac.uk/pdbsum/5ocz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ocz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
This manuscript reports the molecular basis for double-stranded DNA (dsDNA) binding of hairpin polyamides incorporating a 5-alkyl thiazole (Nt) unit. Hairpin polyamides containing an N-terminal Nt unit induce higher melting stabilisation of target dsDNA sequences relative to an archetypical hairpin polyamide incorporating an N-terminal imidazole (Im) unit. However, modification of the N-terminus from Im to Nt-building blocks results in an increase in dsDNA binding affinity but lower G-selectivity. A general G-selectivity trend is observed for Nt-containing polyamide analogues. G-selectivity increases as the steric bulk in the Nt 5-position increases. Solution-based NMR structural studies reveal differences in the modulation of the target DNA duplex of Nt-containing hairpin polyamides relative to the Im-containing archetype. A structural hallmark of an Nt polyamide*dsDNA complex is a more significant degree of major groove compression of the target dsDNA sequence relative to the Im-containing hairpin polyamide. | |||
Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides.,Padroni G, Parkinson JA, Fox KR, Burley GA Nucleic Acids Res. 2017 Nov 29. pii: 4670956. doi: 10.1093/nar/gkx1211. PMID:29194552<ref>PMID:29194552</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 5ocz" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
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Revision as of 07:29, 13 December 2017
Free DNA_hairpin polyamides studies
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