User:Harish Srinivas: Difference between revisions
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[[Image:Nervous system'.jpg|thumb|1000px|centre|Fig7: Expression of S1PR and responses by neural cells. Neural progenitors express S1P1 and S1P2, neurons express S1P1 and S1P3, oligodendrocytes express S1P1 and S1P5, and astrocytes express S1P1 and S1P2. S1P1 couples exclusively to Gαi. S1P2 and S1P3 can couple to GαI, Gα12/13, or Gαq, and S1P5 can couple to GαI or Gα12/13(1).]] | [[Image:Nervous system'.jpg|thumb|1000px|centre|Fig7: Expression of S1PR and responses by neural cells. Neural progenitors express S1P1 and S1P2, neurons express S1P1 and S1P3, oligodendrocytes express S1P1 and S1P5, and astrocytes express S1P1 and S1P2. S1P1 couples exclusively to Gαi. S1P2 and S1P3 can couple to GαI, Gα12/13, or Gαq, and S1P5 can couple to GαI or Gα12/13(1).]] | ||
='''Therapeutic Target'''= | |||
1.The first oral treatment for relapsing multiple sclerosis, the nonselective sphingosine-1-phosphate receptor (S1PR) modulator fingolimod, led to identification of a pivotal role of sphingosine-1-phosphate and one of its five known receptors, S1P1R, in regulation of lymphocyte trafficking in multiple sclerosis. clinical utility of S1P1R modulation for treatment of various immune mediated disorders(11). | |||
2.S1P1 is expressed in both hen and human ovarian tumors. S1P (the ligand for S1P1) has been implicated in the trafficking of immune cells. Immune cells are reported to be involved in the progression of tumors of various organs(10). | |||
='''References'''= | ='''References'''= | ||
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10.Sphingosine-1 phosphate receptor (S1p1), a critical receptor controlling human lymphocyte trafficking, is expressed in hen and human ovaries and ovarian tumors Michael J Bradaric1, Animesh Barua1,2,3, Krishna Penumatsa1, Yu Yi 1, Seby L Edassery1, Sameer Sharma2,4, Jacques S Abramowicz2, Janice M Bahr5, Judith L Luborsky1,2* | 10.Sphingosine-1 phosphate receptor (S1p1), a critical receptor controlling human lymphocyte trafficking, is expressed in hen and human ovaries and ovarian tumors Michael J Bradaric1, Animesh Barua1,2,3, Krishna Penumatsa1, Yu Yi 1, Seby L Edassery1, Sameer Sharma2,4, Jacques S Abramowicz2, Janice M Bahr5, Judith L Luborsky1,2* | ||
11.Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases | |||
Daniele D’Ambrosio, Mark S. Freedman and Joerg Prinz | |||
