6bsf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6bsf is ON HOLD until Paper Publication~~

==Human GR (418-507) in complex with monomeric DNA binding site==

~~Authors: Pufall, M.A.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6bsf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSF FirstGlance]. <br>

~~Description:~~ Human GR (418-507) in complex with monomeric DNA binding site

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsf OCA], [http://pdbe.org/6bsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bsf RCSB], [http://www.ebi.ac.uk/pdbsum/6bsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsf ProSAT]</span></td></tr>

[[Category: Pufall, M.A]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/GCR_SAGOE GCR_SAGOE]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.[UniProtKB:P04150][UniProtKB:P06537]

__TOC__

</StructureSection>

[[Category: Pufall, M A]]

[[Category: Dna binding protein-dna complex]]

[[Category: Glucocorticoid receptor monomeric binding site]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bsf is ON HOLD  until Paper Publication
+==Human GR (418-507) in complex with monomeric DNA binding site==
+<StructureSection load='6bsf' size='340' side='right' caption='[[6bsf]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Pufall, M.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bsf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSF FirstGlance]. <br>
-Description: Human GR (418-507) in complex with monomeric DNA binding site
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsf OCA], [http://pdbe.org/6bsf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bsf RCSB], [http://www.ebi.ac.uk/pdbsum/6bsf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsf ProSAT]</span></td></tr>
-[[Category: Pufall, M.A]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/GCR_SAGOE GCR_SAGOE]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.[UniProtKB:P04150][UniProtKB:P06537]
+__TOC__
+</StructureSection>
+[[Category: Pufall, M A]]
+[[Category: Dna binding protein-dna complex]]
+[[Category: Glucocorticoid receptor monomeric binding site]]