4y1s: Difference between revisions

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==Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes==
==Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes==
<StructureSection load='4y1s' size='340' side='right' caption='[[4y1s]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
<StructureSection load='4y1s' size='340' side='right'caption='[[4y1s]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4y1s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus Mus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y1S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y1S FirstGlance]. <br>
<table><tr><td colspan='2'>[[4y1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y1S FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4y1t|4y1t]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y1s OCA], [https://pdbe.org/4y1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y1s RCSB], [https://www.ebi.ac.uk/pdbsum/4y1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y1s ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Prf1, Pfp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=862507 Mus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y1s OCA], [http://pdbe.org/4y1s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y1s RCSB], [http://www.ebi.ac.uk/pdbsum/4y1s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y1s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE]] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref>
[https://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4y1s" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4y1s" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mus]]
[[Category: Large Structures]]
[[Category: Conroy, P J]]
[[Category: Mus musculus]]
[[Category: Norton, R S]]
[[Category: Conroy PJ]]
[[Category: Whisstock, J C]]
[[Category: Norton RS]]
[[Category: Yagi, H]]
[[Category: Whisstock JC]]
[[Category: C2 domain]]
[[Category: Yagi H]]
[[Category: Calcium binding]]
[[Category: Immune system]]
[[Category: Perforin]]
Retrieved from "https://proteopedia.org/4y1s"