5vok: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5vok is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of the C7orf59-HBXIP dimer==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5vok]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VOK FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vok OCA], [http://pdbe.org/5vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vok RCSB], [http://www.ebi.ac.uk/pdbsum/5vok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vok ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Aparicio, R]]

[[Category: Bar-Peled, L]]

[[Category: Nascimento, A F.Z]]

[[Category: Rasheed, N]]

[[Category: Sabatini, D M]]

[[Category: Shen, K]]

[[Category: Smetana, J H.C]]

[[Category: C7orf59]]

[[Category: Mtor]]

[[Category: Ragulator]]

[[Category: Roadblock]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5vok is ON HOLD  until Paper Publication
+==Crystal structure of the C7orf59-HBXIP dimer==
+<StructureSection load='5vok' size='340' side='right' caption='[[5vok]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5vok]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VOK FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vok OCA], [http://pdbe.org/5vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vok RCSB], [http://www.ebi.ac.uk/pdbsum/5vok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vok ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref>  [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Aparicio, R]]
+[[Category: Bar-Peled, L]]
+[[Category: Nascimento, A F.Z]]
+[[Category: Rasheed, N]]
+[[Category: Sabatini, D M]]
+[[Category: Shen, K]]
+[[Category: Smetana, J H.C]]
+[[Category: C7orf59]]
+[[Category: Mtor]]
+[[Category: Ragulator]]
+[[Category: Roadblock]]
+[[Category: Signaling protein]]