5yx1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5yx1 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of hematopoietic prostaglandin D synthase in complex with U004==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5yx1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YX1 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UX4:ethyl+4-[(8R)-3,8-dimethyl-4-oxo-4,6,7,8,9,10-hexahydrothieno[2,3 4,5]pyrimido[1,2-a]azepin-2-yl]carbamoylpiperazine-1-carboxylate'>UX4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yx1 OCA], [http://pdbe.org/5yx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5yx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yx1 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Aritake, K]]

[[Category: Furubayashi, N]]

[[Category: Inaka, K]]

[[Category: Kamo, M]]

[[Category: Takaya, D]]

[[Category: Tanaka, A]]

[[Category: Urade, Y]]

[[Category: Inhibitor]]

[[Category: Prostaglandin]]

[[Category: Synthase]]

[[Category: Transferase]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yx1 is ON HOLD  until Paper Publication
+==Crystal structure of hematopoietic prostaglandin D synthase in complex with U004==
+<StructureSection load='5yx1' size='340' side='right' caption='[[5yx1]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yx1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YX1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UX4:ethyl+4-[(8R)-3,8-dimethyl-4-oxo-4,6,7,8,9,10-hexahydrothieno[2,3 4,5]pyrimido[1,2-a]azepin-2-yl]carbamoylpiperazine-1-carboxylate'>UX4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yx1 OCA], [http://pdbe.org/5yx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5yx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yx1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Aritake, K]]
+[[Category: Furubayashi, N]]
+[[Category: Inaka, K]]
+[[Category: Kamo, M]]
+[[Category: Takaya, D]]
+[[Category: Tanaka, A]]
+[[Category: Urade, Y]]
+[[Category: Inhibitor]]
+[[Category: Prostaglandin]]
+[[Category: Synthase]]
+[[Category: Transferase]]
+[[Category: Transferase-transferase inhibitor complex]]