6bpm: Difference between revisions

Revision as of 20:24, 2 December 2018

The crystal structure of the Ferric-Catecholate import receptor Fiu from K12 E. coli: Closed form (C21)

Structural highlights

6bpm is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	BOG, POG
Gene:	fiu, ybiL, b0805, JW0790 (ECOLI)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FIU_ECOLI] Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492.^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Patzer SI, Baquero MR, Bravo D, Moreno F, Hantke K. The colicin G, H and X determinants encode microcins M and H47, which might utilize the catecholate siderophore receptors FepA, Cir, Fiu and IroN. Microbiology. 2003 Sep;149(Pt 9):2557-70. doi: 10.1099/mic.0.26396-0. PMID:12949180 doi:https://dx.doi.org/10.1099/mic.0.26396-0
↑ Destoumieux-Garzon D, Peduzzi J, Thomas X, Djediat C, Rebuffat S. Parasitism of iron-siderophore receptors of Escherichia coli by the siderophore-peptide microcin E492m and its unmodified counterpart. Biometals. 2006 Apr;19(2):181-91. doi: 10.1007/s10534-005-4452-9. PMID:16718603 doi:https://dx.doi.org/10.1007/s10534-005-4452-9
↑ Hantke K. Dihydroxybenzoylserine--a siderophore for E. coli. FEMS Microbiol Lett. 1990 Jan 15;55(1-2):5-8. PMID:2139424
↑ Nikaido H, Rosenberg EY. Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups. J Bacteriol. 1990 Mar;172(3):1361-7. PMID:2407721
↑ Curtis NA, Eisenstadt RL, East SJ, Cornford RJ, Walker LA, White AJ. Iron-regulated outer membrane proteins of Escherichia coli K-12 and mechanism of action of catechol-substituted cephalosporins. Antimicrob Agents Chemother. 1988 Dec;32(12):1879-86. PMID:3072926

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OCA

[1] Patzer SI, Baquero MR, Bravo D, Moreno F, Hantke K. The colicin G, H and X determinants encode microcins M and H47, which might utilize the catecholate siderophore receptors FepA, Cir, Fiu and IroN. Microbiology. 2003 Sep;149(Pt 9):2557-70. doi: 10.1099/mic.0.26396-0. PMID:12949180 doi:https://dx.doi.org/10.1099/mic.0.26396-0

[2] Destoumieux-Garzon D, Peduzzi J, Thomas X, Djediat C, Rebuffat S. Parasitism of iron-siderophore receptors of Escherichia coli by the siderophore-peptide microcin E492m and its unmodified counterpart. Biometals. 2006 Apr;19(2):181-91. doi: 10.1007/s10534-005-4452-9. PMID:16718603 doi:https://dx.doi.org/10.1007/s10534-005-4452-9

[3] Hantke K. Dihydroxybenzoylserine--a siderophore for E. coli. FEMS Microbiol Lett. 1990 Jan 15;55(1-2):5-8. PMID:2139424

[4] Nikaido H, Rosenberg EY. Cir and Fiu proteins in the outer membrane of Escherichia coli catalyze transport of monomeric catechols: study with beta-lactam antibiotics containing catechol and analogous groups. J Bacteriol. 1990 Mar;172(3):1361-7. PMID:2407721

[5] Curtis NA, Eisenstadt RL, East SJ, Cornford RJ, Walker LA, White AJ. Iron-regulated outer membrane proteins of Escherichia coli K-12 and mechanism of action of catechol-substituted cephalosporins. Antimicrob Agents Chemother. 1988 Dec;32(12):1879-86. PMID:3072926

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6bpm is ON HOLD  until Paper Publication
+==The crystal structure of the Ferric-Catecholate import receptor Fiu from K12 E. coli: Closed form (C21)==
+<StructureSection load='6bpm' size='340' side='right' caption='[[6bpm]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors: Grinter, R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6bpm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BPM FirstGlance]. <br>
-Description: The crystal structure of the Ferric-Catecholate import receptor Fiu from K12 E. coli: Closed form (C21)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=POG:(20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL'>POG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fiu, ybiL, b0805, JW0790 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpm OCA], [http://pdbe.org/6bpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpm RCSB], [http://www.ebi.ac.uk/pdbsum/6bpm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FIU_ECOLI FIU_ECOLI]] Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492.<ref>PMID:12949180</ref> <ref>PMID:16718603</ref> <ref>PMID:2139424</ref> <ref>PMID:2407721</ref> <ref>PMID:3072926</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Ecoli]]
 [[Category: Grinter, R]]
+[[Category: Antibiotic uptake]]
+[[Category: Ferric-catecholate]]
+[[Category: Iron transporter]]
+[[Category: Membrane protein]]
+[[Category: Membrane transport]]
+[[Category: Tonb-dependent receptor]]

6bpm: Difference between revisions

Revision as of 20:24, 2 December 2018

The crystal structure of the Ferric-Catecholate import receptor Fiu from K12 E. coli: Closed form (C21)

Structural highlights

Function

References

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