6bse: Difference between revisions
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==Glucocorticoid receptor bound to high cooperativity monomer sequence== | |||
<StructureSection load='6bse' size='340' side='right' caption='[[6bse]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSE FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bse OCA], [http://pdbe.org/6bse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bse RCSB], [http://www.ebi.ac.uk/pdbsum/6bse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bse ProSAT]</span></td></tr> | ||
[[Category: Pufall, M | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/GCR_SAGOE GCR_SAGOE]] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.[UniProtKB:P04150][UniProtKB:P06537] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Pufall, M A]] | |||
[[Category: Gene regulation]] | |||
[[Category: Glucocorticoid receptor gene expression protein:dna binding]] | |||
Revision as of 06:33, 5 December 2018
Glucocorticoid receptor bound to high cooperativity monomer sequence
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