5maw: Difference between revisions
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<StructureSection load='5maw' size='340' side='right' caption='[[5maw]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='5maw' size='340' side='right' caption='[[5maw]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5maw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MAW FirstGlance]. <br> | <table><tr><td colspan='2'>[[5maw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MAW FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5maw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5maw OCA], [http://pdbe.org/5maw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5maw RCSB], [http://www.ebi.ac.uk/pdbsum/5maw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5maw ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hag, BSU35360 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835]), fliS, BSU35330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5maw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5maw OCA], [http://pdbe.org/5maw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5maw RCSB], [http://www.ebi.ac.uk/pdbsum/5maw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5maw ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FLA_BACSU FLA_BACSU]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | [[http://www.uniprot.org/uniprot/FLA_BACSU FLA_BACSU]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Flagellin is amongst the most abundant proteins in flagellated bacterial species and constitutes the major building block of the flagellar filament. The proteins FliW and FliS serve in the post-transcriptional control of flagellin and guide the protein to the flagellar type III secretion system (fT3SS), respectively. Here, we present the high-resolution structure of FliS/flagellin heterodimer and show that FliS and FliW bind to opposing interfaces located at the N- and C-termini of flagellin. The FliS/flagellin/FliW heterotrimer is able to interact with FlhA-C suggesting that FliW and FliS are released during flagellin export. After release, FliW and FliS are recycled to execute a new round of post-transcriptional regulation and targeting. Taken together, our study provides a mechanism explaining how FliW and FliS synchronize the production of flagellin with the capacity of the fT3SS to secrete flagellin. | |||
FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis.,Altegoer F, Mukherjee S, Steinchen W, Bedrunka P, Linne U, Kearns DB, Bange G Sci Rep. 2018 Aug 1;8(1):11552. doi: 10.1038/s41598-018-29884-8. PMID:30068950<ref>PMID:30068950</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5maw" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Flagellar protein|Flagellar protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Vibrio subtilis ehrenberg 1835]] | |||
[[Category: Altegoer, F]] | [[Category: Altegoer, F]] | ||
[[Category: Bange, G]] | [[Category: Bange, G]] | ||
