2cii: Difference between revisions
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{{STRUCTURE_2cii| PDB=2cii | SCENE= }} | |||
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'''THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE''' | '''THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE''' | ||
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[[Category: Kojima, M.]] | [[Category: Kojima, M.]] | ||
[[Category: Tormo, J.]] | [[Category: Tormo, J.]] | ||
[[Category: | [[Category: Glycoprotein]] | ||
[[Category: | [[Category: Immune response]] | ||
[[Category: Immunoglobulin domain]] | |||
[[Category: | [[Category: Membrane]] | ||
[[Category: | [[Category: Mhc class i]] | ||
[[Category: | [[Category: Mhc i]] | ||
[[Category: | [[Category: Peptide binding]] | ||
[[Category: | [[Category: Pyrrolidone carboxylic acid]] | ||
[[Category: | [[Category: Sendai virus]] | ||
[[Category: | [[Category: Transmembrane]] | ||
[[Category: | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:13:21 2008'' | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 19:13, 3 May 2008
THE CRYSTAL STRUCTURE OF H-2DB COMPLEXED WITH A PARTIAL PEPTIDE EPITOPE SUGGESTS AN MHC CLASS I ASSEMBLY-INTERMEDIATE
Overview
In the absence of bound peptide ligands, major histocompatibility complex (MHC) class I molecules are unstable. In an attempt to determine the minimum requirement for peptide-dependent MHC class I stabilization, we have used short synthetic peptides derived from the Sendai virus nucleoprotein epitope (residues 324-332, 1FAPGNYPAL9) to promote its folding in vitro of H-2D(b). We found that H-2D(b) can be stabilized by the pentapeptide 5NYPAL9, which is equivalent to the C-terminal portion of the optimal nonapeptide and includes both the P5 and P9 anchor residues. We have crystallized the complex of the H-2D(b) molecule with the pentamer and determined the structure to show how a quasi-stable MHC class I molecule can be formed by occupancy of a single binding pocket in the peptide-binding groove.
About this Structure
2CII is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of H-2D(b) complexed with a partial peptide epitope suggests a major histocompatibility complex class I assembly intermediate., Glithero A, Tormo J, Doering K, Kojima M, Jones EY, Elliott T, J Biol Chem. 2006 May 5;281(18):12699-704. Epub 2006 Feb 14. PMID:16478731 Page seeded by OCA on Sat May 3 22:13:21 2008
