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==Structure of PRL-1 in complex with the Bateman domain of CNNM2==
==Structure of PRL-1 in complex with the Bateman domain of CNNM2==
<StructureSection load='5mmz' size='340' side='right' caption='[[5mmz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5mmz' size='340' side='right'caption='[[5mmz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mmz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MMZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mmz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MMZ FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5lxq|5lxq]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cnnm2, Acdp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Ptp4a1, Prl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmz OCA], [https://pdbe.org/5mmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mmz RCSB], [https://www.ebi.ac.uk/pdbsum/5mmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmz ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmz OCA], [http://pdbe.org/5mmz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mmz RCSB], [http://www.ebi.ac.uk/pdbsum/5mmz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CNNM2_MOUSE CNNM2_MOUSE]] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).<ref>PMID:15899945</ref> [[http://www.uniprot.org/uniprot/TP4A1_MOUSE TP4A1_MOUSE]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity).
[https://www.uniprot.org/uniprot/CNNM2_MOUSE CNNM2_MOUSE] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+).<ref>PMID:15899945</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mmz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mmz" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Mus musculus]]
[[Category: Breiderhoff, T]]
[[Category: Breiderhoff T]]
[[Category: Claverie-Martin, F]]
[[Category: Claverie-Martin F]]
[[Category: Diercks, T]]
[[Category: Diercks T]]
[[Category: Ereno-Orbea, J]]
[[Category: Ereno-Orbea J]]
[[Category: Gimenez-Mascarell, P]]
[[Category: Gimenez-Mascarell P]]
[[Category: Hardy, S]]
[[Category: Hardy S]]
[[Category: Khalaf-Nazzal, R]]
[[Category: Khalaf-Nazzal R]]
[[Category: Kostantin, E]]
[[Category: Kostantin E]]
[[Category: Martinez-Chantar, M L]]
[[Category: Martinez-Chantar ML]]
[[Category: Martinez-Cruz, L A]]
[[Category: Martinez-Cruz LA]]
[[Category: Muller, D]]
[[Category: Muller D]]
[[Category: Oyenarte, I]]
[[Category: Oyenarte I]]
[[Category: Pey, A L]]
[[Category: Pey AL]]
[[Category: Stuiver, M]]
[[Category: Stuiver M]]
[[Category: Tremblay, M L]]
[[Category: Tremblay ML]]
[[Category: Acdp]]
[[Category: Cyclin m]]
[[Category: Magnesium transport]]
[[Category: Metal transport]]
Retrieved from "https://proteopedia.org/5mmz"